International Journal of STD & AIDS > Volume 8, Number 5 > Pp. 307-310

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ichimura, H Articles by Kurimura, T Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

Suppression of HIV replication in vitro by CD8+ T-cells from HIV-infected and HIV-seronegative individuals

H Ichimura, J M Dwyer, H Tsuchie, M A Detorio, M M Hossain, N Tesfamariam, A Trickett, P R Lam-Po-Tang, O Yamada and T Kurimura

The inhibitory effect of CD8+ T-cells from HIV-infected or HIVseronegative individuals on HIV replication in the naturally-infected CD4+ T-cells in vitro was examined. Not only autologous CD8+ T-cells from HIV-infected individuals but also allogeneic CD8+ T-cells from HIV-seronegative individuals prevented or delayed HIV replication, even in transwell cocultures using a semipermeable 0.45 micron filter. The level of the inhibitory effect of allogeneic CD8+ Tcells from the HIV-seronegative individuals on the HIV replication was varied among CD4+ T-cells obtained from HIV-infected individuals used. The results suggested that CD8+ T-cells from HIV-seronegative individuals as well as HIVinfected individuals could produce some cytokine(s) which suppress HIV replication in vitro . The sensitivity to the cytokine(s) might be variable among HIV strains, depending on differences in the nucleotide sequence of different HIV-1 strains. Further studies of control of HIV replication by CD8+ anti-HIV cytokine(s) should provide new strategies for the therapy of HIV infection.

Key Words: T-CELLS • CYTOKINE

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?