International Journal of STD & AIDS > Volume 20, Number 3 > Pp. 145-151

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mahungu, T W Articles by Back, D J Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

Reviews

The impact of pharmacogenetics on HIV therapy

T W Mahungu DTM&H MRCP  ^* , M A Johnson MD FRCP ^*, A Owen MSc PhD  and D J Back PhD 

^* Department of HIV Medicine, Royal Free NHS Trust, Pond Street, London NW3 2QG; Department of Pharmacology and Therapeutics, University of Liverpool, 70 Pembroke Place, Liverpool L69 3GF, UK

Correspondence to: Dr Tabitha W. Mahungu Email: wambura{at}gmail.com

The use of highly active antiretroviral therapy in the treatment of HIV infection has resulted in significant reductions in mortality and morbidity worldwide. However, there is considerable interindividual variability in patient outcomes in terms of drug disposition, drug efficacy and adverse events. The basis of these differences is multifactorial, but host genetics are believed to play a significant part. To date, most attempts to explain this variability have focused on isolated single nucleotide polymorphisms. The most exciting development to date is the discovery of human leukocyte antigen subtype B*5701 (HLA B*5701) as a strong predictor of the abacavir hypersensitivity reaction. There is a gradual move away from single candidate gene analyses towards a high throughput whole genome approach. These studies must be performed on well characterized cohorts and reported associations must be validated in independent, ethnically diverse populations.

Key Words: HIV • HAART • pharmacogenetics • pharmacokinetics • pharmacodynamics

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?