International Journal of STD & AIDS > Volume 19, Number 9 > Pp. 611-616

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Original research articles

Human papillomavirus detection and typification in cutaneous and mucosal lesions of HIV-seropositive patients

Mariana de Gusmão Nunes MD MS ^* , Melissa Azevedo-e-Silva MD ^*, Carolina Pereira Gonçalves MD ^*, Beatriz Moritz Trope MD PhD ^*, Ledy do Horto dos Santos Oliveira PhD  and Marcia Ramos-e-Silva MD PhD ^*

^* Sector of Dermatology and Post Graduation course in Dermatology, Universidade Federal do Rio de Janeiro, Rio de Janeiro; Sector of Virology, Department of Microbiology and Parasitology, Universidade Federal Fluminense, Niterói, Brazil

Correspondence to: Mariana de Gusmão Nunes, Post-graduation Student, Rua Alice 278/402, Laranjeiras, Rio de Janeiro 22241-020, Brazil Email: marianagusmao{at}bol.com.br

High-risk human papillomavirus (HPV) in a lesion is related to an increased chance of neoplasic transformation, especially when with immunosuppression, as in HIV infection. We investigated HPV frequency in cutaneous and mucosal lesions of HIV-seropositive male patients. The frequency of malignancy, its association with the HPV type detected and some clinical variables were also assessed. A total of 38 lesions from 27 patients were studied in a period of 18 months. The biopsied fragment was submitted to HPV detection and typification, through polymerase chain reaction with generic (MY09/11) and specific (types 6, 11, 16 and 18) primers. HPV frequency was 63.2%, with detection of HPV types 6, 11 or 16 in 18 lesions and with multi-infection in three. There was low detection of high-risk HPV (type 16, 18.4%) and no HPV type 18. Of the lesions, 36.8% were already premalignant or malignant, and the frequency of moderate or severe dysplasia was higher in the study patients than that described in the HIV-seronegative population. High-risk HPV (type 16) was detected in four benign lesions and low-risk HPV (type 6) in three premalignant genital lesions. There was no significant association between the clinical variables and an increase in the prevalence of premalignant or malignant lesions.

Key Words: HIV • HPV • homosexual • South America

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