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Int J STD AIDS 2008;19:595-599
doi:10.1258/ijsa.2007.007183
© 2008 Royal Society of Medicine Press

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Original research articles

Genotypic distribution of hepatitis C among hepatitis C and HIV co-infected patients in Brazil

M C Mendes-Correa MD PhD * {dagger} , N P Cavalheiro PhD {dagger}, C Mello PhD {dagger}, A A Barone MD * {dagger} and R J Gianini MD PhD {ddagger}

* Division of Infectious and Parasitic Diseases, Hospital das Clinicas, Medical School; {dagger} Laboratory of Medical Investigation in Hepatitis; {ddagger} Laboratory of Medical Investigation in Epidemiology and Statistics, Medical School, University of São Paulo, São Paulo, Brazil

Correspondence to: Maria Cassia Mendes-Corrêa, Rua André Dreifus, No. 274, SP 01252-010, Brazil Email: cassiamc{at}uol.com.br

Information on hepatitis C virus (HCV) genotypic distribution among HIV-HCV co-infected patients is lacking in Brazil as well as other Latin American countries. The objective of this study was to evaluate the level of exposure to different risk factors associated with HCV transmission among a group of co-infected patients and to characterize the genotypic distribution of HCV in this cluster. A series of 100 HIV-HCV co-infected patients was analysed. The data to be analysed were collected from specific laboratory tests. Information was collected through a questionnaire. HCV genotyping was carried out by sequencing the 5' non-coding region of HCV. Chi-square and Fischer association tests or Kruskal-Wallis test were used to study the association between HCV transmission-related variables and the established genotypes. In conclusion, exposure to multiple risk factors associated with HCV transmission was common among HIV co-infected patients and an association between HCV genotype 3 and intravenous drug user was observed.

Key Words: hepatitis C • hepatitis C virus • genotype • HIV • Latin America


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