International Journal of STD & AIDS > Volume 19, Number 8 > Pp. 570-572

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Case reports

Solid variant of primary effusion lymphoma in successfully treated HIV infection: a case report

E Mylona MD ^* , I G Baraboutis MD , O Georgiou MD , D Rondogianni MD , L J Lekakis MD , V Papastamopoulos MD ^* , I Apostolidis MD ^** and A T Skoutelis MD PhD ^* 

^* Fifth Department of Internal Medicine; Department of Infectious Diseases; Department of Pathology; Department of Hematology, Evaggelismos Hospital, Athens, Greece; ^** Department of Hematology, Oncology and Blood and Marrow Transplantation, University of Kentucky, Lexington, KY, USA

Correspondence to: Dr E Mylona, MD, Fifth Department of Internal Medicine, Evaggelismos Hospital, 45-47 Hipsilantou Street, Kolonaki, GR-106 76 Athens, Greece Email: emylon{at}med.uoa.gr

Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma, mainly met in severely immunocompromised, HIV-positive patients. PEL is aetiologically related to human herpes virus-8 (HHV-8) and it usually presents as a lymphomatous body cavity effusion in the absence of a solid tumour mass. Recently, cases of HIV-positive patients with HHV-8-positive solid tissue lymphomas, not associated with an effusion, have been reported (solid variant of PEL). The prognosis of PEL is reported to be poor. We report a case of an HIV-positive patient with a typical solid variant of PEL without effusion. Interestingly, his disease developed while being on stable antiretroviral therapy (ART) with high CD4 counts. He had a relatively long survival with chemotherapy and ART.

Key Words: primary effusion lymphoma • HIV • HHV-8 • non-Hodgkin lymphoma • solid variant of primary effusion lymphoma

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