International Journal of STD & AIDS > Volume 19, Number 3 > Pp. 208-210

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Case reports

Fulminant autoimmune hepatitis after successful interferon treatment in an HIV–HCV co-infected patient

Romain Coriat MD ^*  and Philippe Podevin MD PhD 

^* Service d'Hépatogastroentérologie, Hôpital Cochin, Paris; Faculté Réné Descartes, Paris 5, France

Correspondence to: Romain Coriat, Service d'Hépatogastroentérologie, Hôpital Cochin, 27, rue du faubourg Saint-Jacques, Paris 75014, France Email: romain.coriat{at}cch.ap-hop-paris.fr

Hepatitis C (HCV) treatment using interferon- (IFN-) and ribavirin is recommended in HIV/HCV co-infected patients to prevent liver cirrhosis and liver-related death. However, in addition to its antiviral activity, IFN is a pleiotropic cytokine able to synergistically amplify T-cell autoreactivity.

Here, we report for the first time the induction of a subfulminant autoimmune hepatitis (AIH) after four months of a successful treatment of HCV-1b infection using peg-IFN and ribavirin, in a 48-year-old woman co-infected with HIV. Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.

Key Words: human immunodeficiency virus • hepatitis C • viral disease

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				E. Vispo, I. Maida, A. Moreno, P. Barreiro, and V. Soriano Autoimmune hepatitis induced by pegylated interferon in an HIV-infected patient with chronic hepatitis C J. Antimicrob. Chemother., October 2, 2008; (2008) dkn416v1. [Full Text] [PDF]