International Journal of STD & AIDS > Volume 19, Number 3 > Pp. 208-210

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Coriat, R. Articles by Podevin, P. Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

Case reports

Fulminant autoimmune hepatitis after successful interferon treatment in an HIV–HCV co-infected patient

Romain Coriat MD ^*  and Philippe Podevin MD PhD 

^* Service d'Hépatogastroentérologie, Hôpital Cochin, Paris; Faculté Réné Descartes, Paris 5, France

Correspondence to: Romain Coriat, Service d'Hépatogastroentérologie, Hôpital Cochin, 27, rue du faubourg Saint-Jacques, Paris 75014, France Email: romain.coriat{at}cch.ap-hop-paris.fr

Hepatitis C (HCV) treatment using interferon- (IFN-) and ribavirin is recommended in HIV/HCV co-infected patients to prevent liver cirrhosis and liver-related death. However, in addition to its antiviral activity, IFN is a pleiotropic cytokine able to synergistically amplify T-cell autoreactivity.

Here, we report for the first time the induction of a subfulminant autoimmune hepatitis (AIH) after four months of a successful treatment of HCV-1b infection using peg-IFN and ribavirin, in a 48-year-old woman co-infected with HIV. Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.

Key Words: human immunodeficiency virus • hepatitis C • viral disease

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Vispo, I. Maida, A. Moreno, P. Barreiro, and V. Soriano Autoimmune hepatitis induced by pegylated interferon in an HIV-infected patient with chronic hepatitis C J. Antimicrob. Chemother., December 1, 2008; 62(6): 1470 - 1472. [Full Text] [PDF]