International Journal of STD & AIDS > Volume 19, Number 3 > Pp. 192-196

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Original research articles

Prevalence and factors associated with anal lesions mediated by human papillomavirus in men with HIV/AIDS

A Pereira MD MSC ^* , H R Lacerda MD PhD ^*   and R R Barros MD PhD 

^* Postgraduate Course on Tropical Medicine; Infectious and Parasitic Diseases Clinic of the University Hospital; Colposcopy and Lower Genital Tract Sector (SCTGI) of the University Hospital, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil

Correspondence to: Heloisa Ramos Lacerda, Infectious and Parasitic Diseases Clinic, Federal University of Pernambuco (UFPE), Professora Anunciada da Rocha Melo, 97 ap 501, Bairro Madalena, Recife, Pernambuco, CEP 50710-390, Brazil Email: helramos{at}terra.com.br

Prevalence and risk factors for human papillomavirus-related anal lesions were evaluated in 60 men with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Patients underwent anal cytology, anuscopy under colposcopic vision and anal biopsy for detection of the lesions. The mean age was 41.9 years and the mean time of HIV infection was 6.8 years, 88.3% of them having been on highly active antiretroviral therapy for an average of 6.5 years. Homosexuals represented 43.3% and bisexuals 15.0% whereas heterosexuals comprised 41.7%. The prevalence of anal lesions detected by anuscopy under colposcopic vision, cytology and biopsy were, respectively, 35.0, 16.7 and 23.3%. Homosexuals or bisexuals accounted for 85.7% of the patients with an abnormal biopsy, the remaining 14.3% being heterosexuals (P = 0.02). The T-CD₄⁺ lymphocyte count, HIV viral load and use of antiretrovirals did not reveal any association with anal lesions. The occurrence of anal lesions was high in the individuals with HIV/AIDS, especially in the homosexuals and bisexuals, but it also occurred in heterosexuals, justifying the screening of anal lesions of all men with the infection.

Key Words: human papillomavirus • anal lesion • HIV/AIDS • anuscopy • anal biopsy

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