International Journal of STD & AIDS > Volume 19, Number 2 > Pp. 118-120

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ORIGINAL RESEARCH ARTICLES

A retrospective clinical study of the treatment of high-grade anal dysplasia by infrared coagulation in a population of HIV-positive men who have sex with men

R D Cranston MD FRCP ^* , S L Hirschowitz MD , G Cortina MD PhD  and A A Moe MD 

^* Department of Infectious Disease, University of Pittsburgh Medical Center, Pittsburgh, PA; Department of Pathology; Department of Infectious Disease, University of California Los Angeles, Los Angeles, CA, USA

Correspondence to: Dr Ross D Cranston, University of Pittsburgh Medical Center, Falk Medical Building, Suite 611, 3601 Fifth Avenue, Pittsburgh PA 15213, USA Email: cranstonr{at}dom.pitt.edu

HIV-positive men who have sex with men (MSM) are at high risk of developing human papillomavirus-associated anal squamous cell cancer. Similar to the management of cervical dysplasia, clinicians are treating high-grade anal dysplasia to prevent progression to cancer. Initial treatments such as cold scalpel excision and electrofulguration have shown limited efficacy in a HIV-positive population. Infrared coagulation (IRC) is an outpatient treatment for high-grade anal dysplasia. This retrospective clinical study reports on 68 HIV-positive MSM with 78 biopsy proven high-grade anal lesions. Each lesion was treated with the IRC with re-biopsy of the treatment site a mean of 140 days later. Of the 74 evaluable lesions; 39 had anal intraepithelial neoplasia (AIN) 1, 20 had AIN 2, seven had AIN 3, and eight had normal epithelium. The IRC showed 64% efficacy per treated lesion and shows promise as a treatment modality for high-grade anal dysplasia in this population.

Key Words: anal • dysplasia • infrared • coagulation

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