International Journal of STD & AIDS > Volume 19, Number 11 > Pp. 789-790

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Case reports

HIV-associated nephropathy in Caucasians: case report and review of literature

R Yalavarthy MD ^* , M L Smith MD  and C L Edelstein MD PhD ^*

^* Department of Renal Diseases and Hypertension; Department of Pathology, University of Colorado Denver, CO, USA

Correspondence to: Dr Rajesh Yalavarthy, University of Colorado, Denver and Health Sciences Center, 4200 E 9th Avenue, Mail Box C281, Denver, CO 80262, USA Email: rajesh.yalavarthy{at}uchsc.edu

HIV-associated nephropathy (HIVAN) is almost exclusively seen in African-Americans (AA) and is rare in Caucasians. The mechanisms responsible for the predilection of HIVAN in AA are not well understood. In transgenic mouse studies, genetic background plays a vital role in the development of the HIVAN phenotype. Larger studies in humans have been initiated to study genetic polymorphisms responsible for HIVAN. As our case illustrates, HIVAN should be considered in Caucasian patients with HIV infection complicated by nephrotic syndrome and renal failure.

Key Words: HIVAN • AA • Caucasians • nephrotic syndrome • transgenic experiments

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