International Journal of STD & AIDS > Volume 19, Number 1 > Pp. 59-61

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CASE REPORT

An acute intracerebral vein thromboses in AIDS with protein C and S deficiency

Luis A Marcos MD ^*, Ruckshanda Majid MD , Nabeel Hamzeh MD , Niraj Mehta MD ^* and Miguel Escobar MD 

^* Internal Medicine Department; Pulmonary Department; Hematology Service, University of Texas Health Science, Houston, TX, USA

Correspondence to: Luis A Marcos, Internal Medicine Department, The University of Texas Medical School at Houston, 6431 Fannin Street, Suite 1.150, Houston, TX 77030, USA Email: Luis.A.Marcos{at}uth.tmc.edu

A 22-year-old woman with advanced AIDS presented with altered mental status. A brain magnetic resonance imaging and angiogram showed extensive dural sinus thromboses of the saggital and bilateral transverse sinuses. CD4 level was low (<15/mm³) and a significant low protein S (7%; normal 54–137%) and C (41%; normal 72–147%) levels were detected. No other hypercoagulable factors were identified. Successful treatment was done with heparin and plasminogen activator catheter-directed thrombolysis were administered. A variety of haematological abnormalities have been observed in human immunodeficiency virus infection. Advanced AIDS might be considered as an acquired hypercoagulable state.

Key Words: AIDS • thromboses • protein C • protein S

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