International Journal of STD & AIDS > Volume 18, Number 8 > Pp. 565-569

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ino, T. Articles by Senpuku, H. Search for Related Content PubMed PubMed Citation Social Bookmarking                      What's this?

Original research articles

Role of salivary tumour necrosis factor in HIV-positive patients with oral manifestations

Tomoaki Ino, Akio Tada, Akira Tominaga, Yasuo Komori, Hiroshige Chiba and Hidenobu Senpuku

Department of Oral Surgery, Tokyo Medical University, Tokyo, Japan; Section of Health Guidance, Chiba City Health Center, Chiba 261-8755, Japan; Department of Oral Surgery, Tokyo Medical University, Tokyo, Japan; Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; Department of Oral Surgery, Tokyo Medical University, Tokyo, Japan; Department of Oral Surgery, Tokyo Medical University, Tokyo, Japan; Department of Bacteriology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan

In HIV-1-infected patients, oral manifestations such as recurrent apthous ulcers are often seen. A total of 29 HIV-infected patients were examined to determine salivary tumour necrosis factor (TNF) concentrations by enzyme-linked immunosorbent assay, the amount of HIV-1 RNA copy by Amplicor HIV-1 Monitor test, number of CD4 cells by flow cytometry and oral manifestations by oral examination. TNF concentration was significantly correlated with the amount of HIV-1 RNA, however, not with the number of CD4 cells in HIV-1-infected patients. Further, patients with oral manifestations showed significantly higher concentrations of TNF in saliva and HIV-1 RNA copies in serum than those without oral manifestations. Following recovery from oral ulcers, TNF concentration was decreased by half to 20 times lower than the level of that during ulcer incidence. Our results suggest that salivary TNF is a good indicator for oral manifestations and HIV RNA amounts in HIV-1-infected patients.

Key Words: TNF ALPHA • HIV • ORAL MANIFESTATIONS • HAART • SALIVA

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?