International Journal of STD & AIDS > Volume 18, Number 8 > Pp. 551-554

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Original research articles

The contribution of APTIMA Combo 2 assay to the diagnosis of gonorrhoea in genitourinary medicine setting

S Moss and H Mallinson

Genito-Urinary Medicine, St Helens Hospital, Marshalls Cross Road, St Helens, Merseyside,UK; Clinical Microbiology and Health Protection Agency Collaborating Laboratory, University Hospital Aintree, Aintree, UK

For 929 female and 821 male patients attending a genitourinary clinic, samples intended for chlamydia diagnosis were dual tested by nucleic acid amplification for both chlamydia and Neisseria gonorrhoeae (NG). The assay used, Gen-probe APTIMA Combo 2 (AC2) detected all cases of NG found by conventional microscopy and culture. AC2 identified additional patients who had partners with NG, but were themselves negative by microscopy and culture. Few, if any, false-positive AC2 results were found. Use of AC2 increased the number of patients treated for NG. It can reduce the number of specimens required and may limit the need for multiple site testing.

Key Words: SEXUAL HEALTH TARGETS • APTIMA COMBO 2 • NATIONAL CLINICAL OPERATING PROCEDURE • GONORRHOEA FALSE-POSITIVES • POSITIVE PREDICTIVE VALUE • NEAR PATIENT TESTING FOR GONORRHOEA MORE ACCEPTABLE • NUCLEIC ACID AMPLIFICATION TESTS

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This article has been cited by other articles:

				B. Serisha, M. Sillis, and J. Evans Confirmation of reactive gonorrhoea Gen Probe APTIMA Combo 2 assay using the alternative sequence mono-specific APTIMA gonococcus assay Int J STD AIDS, January 1, 2008; 19(1): 69 - 69. [Full Text] [PDF]