International Journal of STD & AIDS > Volume 18, Number 6 > Pp. 365-368

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Original research articles

Comparison of the effectiveness of commonly used clinic-based treatments for external genital warts

Jackie Sherrard and Lynn Riddell

Department of Genitourinary Medicine, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK; Department of Genitourinary Medicine, Northampton General Hospital, Billing Road, Northampton, UK

We describe a prospective study designed to assess the effectiveness of the commonly used clinic-based treatments for genital warts individually and in combination. Patients presenting with new or recurrent genital warts were randomly allocated to one of five treatments on a weekly basis. The clinical endpoint was wart clearance or eight treatments, whichever occurred sooner. If there was not a good response by the eighth treatment, an alternate modality was offered. Four hundred and nine individuals were enrolled in the study. Almost no patients withdrew in any group due to adverse effects. Three-quarters of patients treated with podophyllin 25% and cryotherapy concurrently required only two treatments to clear their warts. All had clearance in less than eight treatments. Single therapy with either trichloracetic acid or podophyllin 25% resulted in longer time to wart clearance, and more persistent warts.

Key Words: GENITAL WARTS • TRICHLOROACETIC ACID • CRYOTHERAPY • PODOPHYLLIN

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