International Journal of STD & AIDS > Volume 18, Number 2 > Pp. 138-139

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Case reports

Immune reconstitution sarcoidosis presenting with hypercalcaemia and renal failure in HIV infection

R A Ferrand, J D Cartledge, J Connolly, R A Standish and R F Miller

University College London Hospitals, London NW1 2BU, UK; Camden Primary Care Trust, Mortimer Market Centre, London WC1E 6AU, UK; University College London Hospitals, London NW1 2BU, UK; Camden Primary Care Trust, Mortimer Market Centre, London WC1E 6AU, UK; University College London Hospitals, London NW1 2BU, UK; Department of Nephrology, University College London, London W1N 8AA, UK; Academic Department of Histopathology, Royal Free and University College Medical School, London NW3 2PF, UK; University College London Hospitals, London NW1 2BU, UK; Centre for Sexual Health and HIV Research, Royal Free and University College Medical School, University College London, London WC1E 6AU, UK

An HIV-positive white man developed hypercalcaemia and renal failure 15 months after starting highly active antiretroviral therapy. Investigations showed systemic sarcoidosis affecting parotids, skin and kidneys. This presentation was thought to be a manifestation of immune reconstitution inflammatory syndrome, and the patient was successfully treated with corticosteroid therapy.

Key Words: HIV • HYPERCALCAEMIA • IRIS • SARCOIDOSIS • RENAL FAILURE

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