International Journal of STD & AIDS > Volume 18, Number 1 > Pp. 28-32

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Original research articles

HIV-infected pregnant women have greater adherence with antiretroviral drugs than non-pregnant women

Maria José Rodrigues Vaz, Sonia Maria Oliveira Barros, Ricardo Palacios, Jorge Figueiredo Senise, Luciana Lunardi, Abes Mahmed Amed and Adauto Castelo

Multidisciplinary Group for Infectious Diseases on Pregnancy – NUPAIG, Hospital São Paulo, Departments of Infectious Diseases, and Obstetrics, Federal University of São Paulo – UNIFESP /Escola Paulista de Medicina, Sao Paulo, Brazil; Multidisciplinary Group for Infectious Diseases on Pregnancy – NUPAIG, Hospital São Paulo, Departments of Infectious Diseases, and Obstetrics, Federal University of São Paulo – UNIFESP /Escola Paulista de Medicina, Sao Paulo, Brazil; Multidisciplinary Group for Infectious Diseases on Pregnancy – NUPAIG, Hospital São Paulo, Departments of Infectious Diseases, and Obstetrics, Federal University of São Paulo – UNIFESP /Escola Paulista de Medicina, Sao Paulo, Brazil; Multidisciplinary Group for Infectious Diseases on Pregnancy – NUPAIG, Hospital São Paulo, Departments of Infectious Diseases, and Obstetrics, Federal University of São Paulo – UNIFESP /Escola Paulista de Medicina, Sao Paulo, Brazil; Multidisciplinary Group for Infectious Diseases on Pregnancy – NUPAIG, Hospital São Paulo, Departments of Infectious Diseases, and Obstetrics, Federal University of São Paulo – UNIFESP /Escola Paulista de Medicina, Sao Paulo, Brazil; Multidisciplinary Group for Infectious Diseases on Pregnancy – NUPAIG, Hospital São Paulo, Departments of Infectious Diseases, and Obstetrics, Federal University of São Paulo – UNIFESP /Escola Paulista de Medicina, Sao Paulo, Brazil; Multidisciplinary Group for Infectious Diseases on Pregnancy – NUPAIG, Hospital São Paulo, Departments of Infectious Diseases, and Obstetrics, Federal University of São Paulo – UNIFESP /Escola Paulista de Medicina, Sao Paulo, Brazil

The objective of the study was to evaluate the influence of pregnancy on the level of adherence with antiretroviral (ARV) drugs, in a prospective cohort of 72 pregnant women and 79 non-pregnant women. Adherence was measured by pill counting and self-reporting. Women were deemed adherent if 95% or more of all ARV had been taken as prescribed, in two occasions. According to pill counting, 43.1 and 17.7% of pregnant and non-pregnant women, respectively, met the criteria of adherence (P = 0.001); in the postpartum, adherence declined to 20.6% (P = 0.002). In both groups, adherence rates by self-reporting were significantly higher as compared with pill counting (P = 0.001). In multivariate regression analysis, age >29 years (odds ratio [OR] 3.58, confidence interval [CI] 95% 0.10–0.75, P = 0.011), mean number of pills/day <6 (OR 2.53, CI 95% 1.07–6.01, P = 0.035), and being pregnant (OR 3.33, CI 95% 1.36–8.13, P = 0.008) were independently associated to greater adherence.

Key Words: ADHERENCE • ARV THERAPY • HIV • PREGNANCY • PILL COUNTING

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