International Journal of STD & AIDS > Volume 17, Number 4 > Pp. 257-259

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Original research articles

Cohort analysis of two multidisciplined adherence intervention programmes for patients on antiretroviral therapy

A Doxanakis, T Read, R Levy, A Mijch and C K Fairley

Department of Public Health, University of Melbourne, Melbourne, Australia; Melbourne Sexual Health Centre, Melbourne, Australia; Melbourne Sexual Health Centre, Melbourne, Australia; Department of Pharmacy, The Alfred Hospital, Melbourne, Australia; Department of Infectious Diseases, The Alfred Hospital, Melbourne, Australia; Department of Public Health, University of Melbourne, Melbourne, Australia; Melbourne Sexual Health Centre, Melbourne, Australia

The aim was to analyse data from two randomized controlled trials (RCTs) to determine if an adherence intervention programme for antiretroviral therapy (ART) resulted in a reduction in viral load. A cohort analysis of pre- and post-intervention viral loads and CD4 counts using paired analysis was undertaken on participants who received the intervention programme. Analysis was also undertaken on a control group. The intervention participants had an increase in mean CD4 count (450–478, P = 0.26), and a decline in log viral load (2.48–2.36, P = 0.056). The control group had a decline in mean CD4 counts (596–570, P = 0.53), and an increase in log viral load (2.09–2.11, P = 0.78). The use of an adherence intervention programme is associated with a decrease in mean viral load, which is in contrast to the control group that demonstrated an increase in viral load over time.

Key Words: ANTIRETROVIRAL • HIV • INTERVENTION • ADHERENCE

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